TY - JOUR
AU - Aouf, Nour‐Eddine
AB -  INTRODUCTION Substituted acylsulfonamides have been widely used as carboxylic acid bioisosteres in medicinal chemistry because of their comparable acidity . They have received considerable attention because of their diverse biological activities as precursors of therapeutic agents for Alzheimer's disease , as antibacterial inhibitors of tRNA synthetases , as antagonists for angiotensin II , as leukotriene D 4 ‐receptors , and as protease inhibitors . Some of these compounds were employed for designing many types of therapeutic agents. Some clinically used HIV protease inhibitors possess sulfonamide moieties in their structure. In addition, several N ‐acyl‐ N ‐(2,3,4,5,6‐pentafluorophenyl) methane sulfonamide have been used as chemoselective N‐acylating reagents . Katritzky et al . reported N‐acylation of sulfonamides using N ‐acyl benzotriazole as an acylating agent. A very large number of other derivatives are constantly being synthesized and evaluated to obtain compounds with lower toxicity or increased activity against viruses resistant to such first‐generation drugs. The synthesis of N ‐acylsulfonamide 1 , which is an analogue of β‐aspartyl‐AMP, is described . This compound appears to be the first potent inhibitor of human asparagine synthetase. Also, the synthesis of acylsulfonamides using a convenient method with polymer‐supported reagents has been described . The preparation 
TI - Synthesis and Biological Activity of New Chiral N ‐Acylsulfonamide Bis‐oxazolidin‐2‐ones
JF - Journal of Heterocyclic Chemistry
DO - 10.1002/jhet.1987
DA - 2013-11-01
UR - https://www.deepdyve.com/lp/wiley/synthesis-and-biological-activity-of-new-chiral-n-acylsulfonamide-bis-RCaw5YDdxq
SP - 1328
EP - 1332
VL - 50
IS - 6
DP - DeepDyve
ER -