TY - JOUR
AU - Liggitt, Denny
AB - THE JOURNAL OF INFECTIOUS DISEASES· VOL. 159, NO.2. FEBRUARY 1989 © 1989 by The University of Chicago. All rights reserved. 0022-1899/89/5902-0020$01.00 Enhancement of Simian Varicella Virus Infection in African Green Monkeys by Recombinant Human Tumor Necrosis Factor (l Tumor necrosis factor u (TNF-u), also termed cachectin, Materials and Methods was first described as a substance in the sera of mice chal­ lenged with endotoxin that, upon injection, induced SVV infection of monkeys and evaluation of antiviral ac­ hemorrhagic necrosis of certain murine transplantable tivity of administered antiviral drugs has previously been described [8,9]. In brief, 12 monkeys free of antibody to tumors [I]. TNF-u has been thought to be a mediator in­ duced by lipopolysaccharide (LPS) that is responsible for SVV were infected by combined intratracheal and sc in­ many of the actions of LPS. In the past several years, oculation of 1.5 x 10 pfu of SVv. rHuTNF-o. was pro­ studies with purified preparations of recombinant TNF-o. duced in Escherichia coli [2] and was purified and charac­ have demonstrated the broad spectrum of biologic activi­ terized at Genentech (South San Francisco, Calif). Vials ties attributed to this cytokine, including a significant role containing 1 mg of rHuTNF-o. in 
TI - Enhancement of Simian Varicella Virus Infection in African Green Monkeys by Recombinant Human Tumor Necrosis Factor α
JF - The Journal of Infectious Diseases
DO - 10.1093/infdis/159.2.331
DA - 1989-02-01
UR - https://www.deepdyve.com/lp/oxford-university-press/enhancement-of-simian-varicella-virus-infection-in-african-green-RCEmXEEeal
SP - 331
EP - 334
VL - 159
IS - 2
DP - DeepDyve
ER -