TY - JOUR
AU - DIANZANI, F
AB - SUMMARY It is known that IFN therapy can induce the development of anti-IFN antibodies. In order to evaluate the biological and clinical significance of both neutralizing (NA) and non-neutralizing (binding) antibodies, 123 patients with chronic hepatitis C treated with recombinant IFN-α were examined. Among them, 15 were positive for NA and 24 for binding antibodies. The kinetics of NA appearance show that, in general, they develop early during the first 3 months of treatment. Moreover, NA seem to be clinically relevant, since they may be responsible for non-responsiveness to treatment in 53% of patients who develop them. The evaluation of the clinical significance of binding antibodies is more difficult. They appear significantly earlier in non-responders than in responders, but no differences were observed in the overall percentage of seroconversion between responders and non-responders. 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J Interferon Res 1993 ; 13 : 57 – 60 . Google Scholar Crossref Search ADS PubMed WorldCat This content is only available as a PDF. This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model)
TI - Biological and clinical significance of neutralizing and binding antibodies to interferon-alpha (IFN–α) during therapy for chronic hepatitis C
JO - Clinical & Experimental Immunology
DO - 10.1111/j.1365-2249.1994.tb06571.x
DA - 2008-06-28
UR - https://www.deepdyve.com/lp/oxford-university-press/biological-and-clinical-significance-of-neutralizing-and-binding-R0cGklg3hc
SP - 4
EP - 9
VL - 97
IS - 1
DP - DeepDyve
ER -