TY - JOUR
AU - Baron, Samuel
AB - Fifteen children ranging in age from one and one-half to 14 years received intravenous polyriboinosinic-polyribocytidylic acid [poly (I) • poly (C)], an interferon inducer. The patients all had serious neurologic illness either directly or circumstantially related to viral infection. Peak titers of interferon in serum ranged from 8 to 500 units/ml in re~ponse to doses of poly (I) • poly (C) of 0.1–1.0 mg/kg. Serum interferon persisted for ⩽24 hr after induction. Hyporesponsiveness to a second dose of poly (I) • poly (C) persisted for seven days after initial induction, after which time full response again occurred. The half-life of poly (I) • poly (C) in plasma as measured in three patients was <30 min. Poly (I) • poly (C) appears to be safe when given intravenously, but the low titers of interferon induced may limit its clinical usefulness as an antiviral drug.
TI - Clinical Studies of an Interferon Inducer, Polyriboinosinic-Polyribocytidylic Acid [Poly (I) • Poly (C)], in Children
JF - The Journal of Infectious Diseases
DO - 10.1093/infdis/136.1.50
DA - 1977-07-01
UR - https://www.deepdyve.com/lp/oxford-university-press/clinical-studies-of-an-interferon-inducer-polyriboinosinic-QypU3a5kao
SP - 50
EP - 58
VL - 136
IS - 1
DP - DeepDyve
ER -