TY - JOUR
AU1 - Zhang, Qinglin
AU2 - Duan, Yongbin
AU3 - Guo, Huifeng
AU4 - Yang, Hong
AU5 - Zhai, Jiulong
AU6 - Li, Tiantian
AU7 - Wang, Zhihai
AU8 - Lu, Xiaolei
AU9 - Wang, Yan
AU1 - Yin, Yan
AB - A Bi(OTf)3‐catalyed reaction of 3‐aryl propargyl alcohols with sulfonamide and halogen source was firstly investigated, which provided a facile route for the synthesis of a large variety of α‐halo‐β‐amino ketones. The key intermediates, β‐amino ketones, were obtained through tandem Meyer‐Schuster rearrangement reaction of propargyl alcohols and intermolecular Michael addition of α, β‐unsaturated ketones and sulfonamide. Then the in situ generated α‐halo‐β‐amino ketones underwent the base‐promoted intramolecular cyclization to give diverse acyl aziridines in a one‐pot fashion. These transformations are reliable on a large scale. The high yields and convenient experimental operations make it a valuable method for the construction of α‐halo‐β‐amino ketones and acyl aziridine derivatives.
TI - Bi(OTf)3‐catalyed One‐pot Synthesis of α‐Halo‐β‐amino Ketones and Acyl Aziridines from 3‐Aryl Propargyl Alcohols
JF - Chemistry - An Asian Journal
DO - 10.1002/asia.202100368
DA - 2021-07-05
UR - https://www.deepdyve.com/lp/wiley/bi-otf-3-catalyed-one-pot-synthesis-of-halo-amino-ketones-and-acyl-Qigq53BRM3
SP - 1832
EP - 1838
VL - 16
IS - 13
DP - DeepDyve
ER -