TY - JOUR
AU - Henry,  Monique
AB - C-kit immunocytochemistry was performed on ultrathin sections of human distal colon. Our attention was focused on relationships between c-kit immunoreactive interstitial cells (c-kit ICs) and muscular cells and nervous elements located in the external muscular layers of the colonic wall. C-kit ICs established membrane apposition with both nerve fibers and smooth muscle cells of, respectively, the longitudinal and circular muscle layers, the myenteric area, and the extremus submucosus plexus. C-kit ICs also surrounded the external submucosus plexus and established membrane appositions with nerve elements located inside the myenteric ganglia. These membrane appositions were observed either at the level of the c-kit IC bodies or at that of their cytoplasmic processes. In some cases, membrane appositions were observed concomitantly between the c-kit ICs, nerve fibers, and smooth muscle cells. In all the regions studied, the c-kit ICs were also found to be located in the close vicinity of blood vessels and to have established close contacts with non-immunoreactive fibroblast-like cells. The results of the present study shed essential light on the relationships of c-kit ICs with the neighboring muscle cells and nerve elements, and confirm that the intercalated c-kit ICs well fit with the so-called "interstitial cells of Cajal".
TI - Ultrastructural study of relationships between c-kit immunoreactive interstitial cells and other cellular elements in the human colon
JF - Histochemistry and Cell Biology
DO - 10.1007/s004180000154
DA - 2000-05-01
UR - https://www.deepdyve.com/lp/springer-journals/ultrastructural-study-of-relationships-between-c-kit-immunoreactive-QdkNVPKG2c
SP - 401
EP - 411
VL - 113
IS - 5
DP - DeepDyve
ER -