TY - JOUR
AU1 - Sharma, Upma
AU2 - Concagh, Danny
AU3 - Core, Lee
AU4 - Kuang, Yina
AU5 - You, Changcheng
AU6 - Pham, Quynh
AU7 - Zugates, Greg
AU8 - Busold, Rany
AU9 - Webber, Stephanie
AU1 - Merlo, Jonathan
AU1 - Langer, Robert
AU1 - Whitesides, George M.
AU1 - Palasis, Maria
AB - Implants for the treatment of tissue defects should mimic the mechanical properties of the native tissue of interest and should be resorbable as well as biocompatible. In this work, we developed a scaffold from variants of poly(glycolic) acid which were braided and coated with an elastomer of poly(glycolide-co-caprolactone) and crosslinked. The coating of the scaffold with the elastomer led to higher mechanical strength in terms of compression, expansion and elasticity compared to braids without the elastomer coating. These composite scaffolds were found to have expansion properties similar to metallic stents, utilizing materials which are typically much weaker than metal. We optimized the mechanical properties of the implant by tuning the elastomer branching structure, crosslink density, and molecular weight. The scaffolds were shown to be highly resorbable following implantation in a porcine femoral artery. Biocompatibility was studied in vivo in an ovine model by implanting the scaffolds into femoral arteries. The scaffolds were able to support an expanded open lumen over 12 months in vivo and also fully resorbed by 18 months in the ovine model.
TI - The development of bioresorbable composite polymeric implants with high mechanical strength
JF - Nature Materials
DO - 10.1038/nmat5016
DA - 2017-11-20
UR - https://www.deepdyve.com/lp/springer-journals/the-development-of-bioresorbable-composite-polymeric-implants-with-QbyL9ALd3E
SP - 96
EP - 103
VL - 17
IS - 1
DP - DeepDyve
ER -