TY - JOUR
AU1 - Nyberg, Nils
AU2 - Nielsen, Mette
AU3 - Jaroszewski, Jerzy
AB - 
1H NMR metabolic profiles of urine from sheep exposed to prenatal nutritional restriction (n = 19) and a control group with normal prenatal nutritional requirements (n = 19), followed by either conventional (n = 10 + 10) or high carbohydrate high fat postnatal diet (n = 9 + 9), were studied. Urine was sampled from 2, 6, 19 and 24-month-old animals receiving differential dietary treatments during the first 6 months and the same normal diet later. Principal component analysis of 1H NMR spectra (n = 164) showed a V-shaped metabolic trajectory as a function of age and diet, starting with urines with a high amount of glucose, indicative of monogastric-like metabolism, and exhibiting concomitant increase of metabolites related to rumen microflora (mainly glycine conjugates of benzoic and phenylacetic acid) as the ruminal metabolism developed. Urines from young (2-month-old) animals exposed to prenatal undernutrition followed by normal postnatal diet showed metabolic patters that are ahead in time on the metabolic trajectory relative to the prenatal control group. No long-term effects of fetal undernutrition, alone or in combination with postnatal hypernutrition were observed.
TI - Metabolic trajectories based on 1H NMR spectra of urines from sheep exposed to nutritional challenges during prenatal and early postnatal life
JF - Metabolomics
DO - 10.1007/s11306-010-0229-4
DA - 2010-07-10
UR - https://www.deepdyve.com/lp/springer-journals/metabolic-trajectories-based-on-1h-nmr-spectra-of-urines-from-sheep-QX25rapyL8
SP - 489
EP - 496
VL - 6
IS - 4
DP - DeepDyve
ER -