TY - JOUR
AU - Shelesnyak, M C
AB - ABSTRACTThe ovarian content of progesterone (P) and 20α-hydroxy-pregn-4-en-3-one (20αOHP) was measured in rats given a subcutaneous injection of 1 mg ergocornine methanesulphate (ECO) on day L4 of pseudopregnancy and in untreated pseudopregnant controls. The progesterone content in the ovaries of the treated rats declined, after a latency of 12 h, to 44% of the control level at 24 h, and to 30% at 30 to 72 h after the ECO injection. This fall in progesterone level coincided with a sharp rise in 20αOHP content of the ovaries and consequent inversion of the P/20αOHP ratio, from 1.9–3.8 in the controls to 0.24–0.45 in the ECO-treated rats. The total P + 20αOHP content of the ovaries remained similar in treated and control rats, except for a significant fall 48 h after ECO injection. The changes in ovarian steroid content after ECO administration mimic those observed during spontaneous prooestrus and oestrus and account for the interruption of the progestational state brought about by the drug. The results negate the postulate that ECO exerts its pregnancy-interrupting action in the rat by direct inhibition of ovarian 3β-hydroxysteroid dehydrogenase and are consistent with the view that this action of the drug is mediated by suppression of prolactin secretion by the pituitary gland; such a suppression may be secondary to an excitatory effect on the hypothalamus.
TI - EFFECT OF ERGOCORNINE ON OVARIAN SYNTHESIS OF PROGESTERONE AND 20α-HYDROXY-PREGN-4-EN-3-ONE IN THE PSEUDOPREGNANT RAT
JF - European Journal of Endocrinology
DO - 10.1530/acta.0.0560027
DA - 1967-09-01
UR - https://www.deepdyve.com/lp/oxford-university-press/effect-of-ergocornine-on-ovarian-synthesis-of-progesterone-and-20-QKDpmDMbnK
SP - 27
EP - 34
VL - 56
IS - 1
DP - DeepDyve
ER -