TY - JOUR
AU - Scibienski, Robert
AB - Transfer factor (TF) is a dialyzable extract from primed lymphocytes that is able to transfer specific delayed hypersensitivity from one animal to another. On the basis of available data we suggest that TF is a polypeptide with a molecular weight below 15,000 daltons. We hypothesize that TF is the variable light or heavy chain domain of immunoglobulin; such a molecule conforms with the accepted properties of TF and also has the necessary specificity requirements. We also hypothesize that TF is part of a receptor site. β-2-microglobulin, a molecule that is an integral part of cell surfaces, could be the anchor for TF. β-2-microglobulin has homologies with the constant portion of immunoglobulin light or heavy chain and thus would combine with the variable domain (TF) to form a complete receptor site for a specific antigen. The properties of TF suggest its mode of action, which is discussed in detail in the text. The biologic advantage of TF is its ability to confer immediate (immunologic specific) protection while the ‘normal’ immune response develops.
TI - Transfer Factor – Hypotheses for its Structure and Function
JO - Oncology
DO - 10.1159/000225076
DA - 1975-01-01
UR - https://www.deepdyve.com/lp/karger/transfer-factor-hypotheses-for-its-structure-and-function-QFjz0hw6Ut
SP - 269
EP - 274
VL - 32
IS - 5-6
DP - DeepDyve
ER -