TY - JOUR
AU1 - EL‐mahdy, Kamelia M.
AU2 - Farouk, Osama
AB - 8‐Chloro‐7‐formyl‐4‐oxo‐2‐phenyl‐4H‐pyrimido[1,2‐a]pyrimidine‐3‐carbonitrile (3) is constructed using N‐(5‐cyano‐6‐oxo‐4‐phenyl‐1,6‐dihydropyrimidin‐2‐yl) acetamide (2) via Vilsmeier‐Haack formylation reaction. Compound 3 reacted with 3‐(triethoxysilyl)propan‐1‐amine under different conditions. Condensation of pyrimidopyrimidine 3 with thiosemicarbazone derivative gave Schiff base 8, which upon treating with Vilsmeier‐Haack reagent afforded pyrazole carbothioamide 9. Cyclocondensation of compound 3 with some binucleophiles namely thiocarbohyrazide, hydrazine carbodithioic acid, benzyl hydrazinecarbodithioate and/or 2‐thioxopyrimidinone was investigated. Structures of the new synthesized compounds were confirmed by their analytical and spectral data.
TI - Easy preparation, characterization and reactions of new 8‐chloro‐7‐formyl‐4‐oxo‐2‐phenyl‐4H‐pyrimido[1,2‐a]pyrimidine‐3‐carbonitrile
JF - Journal of Heterocyclic Chemistry
DO - 10.1002/jhet.4237
DA - 2021-05-01
UR - https://www.deepdyve.com/lp/wiley/easy-preparation-characterization-and-reactions-of-new-8-chloro-7-QAEEARzvS7
SP - 1070
EP - 1078
VL - 58
IS - 5
DP - DeepDyve
ER -