TY - JOUR AU1 - Wang, Zhen-fei AU2 - Ma, Da-guang AU3 - Wang, Ling AU4 - Feng, Li AU5 - Fu, Jian-wei AU6 - Li, Ying AU7 - Wang, Dan-ting AU8 - Jia, Yong-feng AB - Chin J Integr Med 2019 Nov;25(11):837-844 • • Available online at link.springer.com/journal/11655 hinese Journal of Integrative Medicine Journal homepage: www.cjim.cn/zxyjhen/zxyjhen/ch/index.aspx E-mail: cjim_en@cjim.cn Original Article Paeonifl orin Inhibits Migration- and Invasion-Promoting Capacities of Gastric Cancer Associated Fibroblasts 1 1 2 2 3 WANG Zhen-fei , MA Da-guang , WANG Ling , FENG Li , FU Jian-wei , 2 2 1 LI Ying , WANG Dan-ting , and JIA Yong-feng A ABSTRACT BSTRACT Objective Objective:: To investigate the inhibitory effects of paeoniflorin on migration- and invasion- To investigate the inhibitory effects of paeoniflorin on migration- and invasion- promoting promoting capacities of gastric cancer associated capacities of gastric cancer associated fi fi broblasts broblasts (GCAFs) and to explore the molecular mechanism (GCAFs) and to explore the molecular mechanism u underlying the effects. nderlying the effects. M Methods ethods:: Paired gastric normal Paired gastric normal fi fi b broblast (GNF) and GCAF cultures were established roblast (GNF) and GCAF cultures were established ffrom resected tissues. GCAFs were treated with control medium, or 2.5, 5 or 10 rom resected tissues. GCAFs were treated with control medium, or 2.5, 5 or 10 μμg g/mL paeoniflorin. /mL paeoniflorin. Conditioned Conditioned media were prepared from GNFs, GCAFs, TI - Paeoniflorin Inhibits Migration- and Invasion-Promoting Capacities of Gastric Cancer Associated Fibroblasts JF - Chinese Journal of Integrative Medicine DO - 10.1007/s11655-018-2985-3 DA - 2018-10-25 UR - https://www.deepdyve.com/lp/springer-journals/paeoniflorin-inhibits-migration-and-invasion-promoting-capacities-of-PtbftjXRcC SP - 837 EP - 844 VL - 25 IS - 11 DP - DeepDyve ER -