TY - JOUR AU - Slater, J D H AB - POSTGRAD. MED. J. (1964), 479 40, THE HORMONAL OF CONTROL BODY SODIUM J. D. H. SLATER, M.A., M.B., M.R.C.P. First Assistant, The Medical Unit, Middlesex Hospital, W.I. OUR body cells are bathed in a fluid maintain a whose state. steady Large changes of salt content resembles that of the intake induce primordial small only very changes in sea where we had presumably our origins sodium a reabsorption; of 0.75 change only per several billion Since this years ago. sea cent in the amount of sodium realbsorbed will probably contained about one-third as much maintain a steady state despite doubling or salt as sea-water its to-day (Strauss, 1957) salt an halving average salt intake. Therefore, the content approached that of our extracellirlar mechanism(s) by which the kidney is able to fluid. invertebrates Among there are wide detect and to respond changes in salt intake variation in the osmotic concentration of must be sensitive indeed. very but the body fluids, "milieu int6rieur" of man and all classes of vertebrates is remarkably Mechanism of Salt Excretion constant, both and osmotically volumetrically. Much data is now available which strongly suggests Claude Bernard's (1878) oft-quoted idea that that the volume of the extracellular fluid TI - The Hormonal Control of Body Sodium JO - Postgraduate Medical Journal DO - 10.1136/pgmj.40.466.479 DA - 1964-08-01 UR - https://www.deepdyve.com/lp/oxford-university-press/the-hormonal-control-of-body-sodium-PlTuIrlYRg SP - 479 EP - 496 VL - 40 IS - 466 DP - DeepDyve ER -