TY - JOUR
AU1 - Jordan, M. Colin
AU2 - Takagi, JoAnn L.
AU3 - Stevens, Jack G.
AB - Many cytomegalovirus (CMV) infections result from activation of virus previously latentin the host. Murine models of latent CMV infection have been developed in whichlatent virus can be activated in vivo by immunosuppression or by coculture of spleniclymphocytes in vitro. In the present study, latent murine CMV (MCMV) could be activatedfrom lymphocytes of mice regardless of genetic strain, age at time of virus inoculation,or use of syngeneic or allogeneic fibroblasts for coculture. After intraperitonealinoculation, virulent virus was activated from lymphocytes more often than attenuatedMCMV (69% vs. 20% of lymphocyte cocultures were positive, respectively).Latent MCMV was not detected in lymphocytes after subcutaneous inoculation ofweanling mice but could be activated from mice infected subcutaneously as newborns.The absence of latent infection in the lymphocytes of the mice that had been inoculatedas weanlings was due to lack of virus replication in the spleen during acute infection.
TI - Activation of Latent Murine Cytomegalovirus in Vivo and in Vitro: A Pathogenetic Role for Acute Infection
JF - The Journal of Infectious Diseases
DO - 10.1093/infdis/145.2.699
DA - 1982-05-01
UR - https://www.deepdyve.com/lp/oxford-university-press/activation-of-latent-murine-cytomegalovirus-in-vivo-and-in-vitro-a-P80Zs09Lli
SP - 699
EP - 705
VL - 145
IS - 5
DP - DeepDyve
ER -