TY - JOUR
AU1 - Jayaraj, Richard
AU2 - Rodriguez, Eric
AU3 - Wang, Yi
AU4 - Block, Michelle
AB - Curr Envir Health Rpt (2017) 4:166–179 DOI 10.1007/s40572-017-0142-3 MECHANISMS OF TOXICITY (JR RICHARDSON, SECTION EDITOR) Outdoor Ambient Air Pollution and Neurodegenerative Diseases: the Neuroinflammation Hypothesis 1 1 2 1 Richard L. Jayaraj & Eric A. Rodriguez & Yi Wang & Michelle L. Block Published online: 25 April 2017 Springer International Publishing AG 2017 Abstract forms of air pollution, suggesting a potential common delete- Purpose of Review Accumulating research indicates that ambi- rious pathway. ent outdoor air pollution impacts the brain and may affect neu- Summary Multiple direct and indirect pathways in response to rodegenerative diseases, yet the potential underlying mechanisms air pollution exposure likely interact in concert to exert CNS are poorly understood. effects. Recent Findings The neuroinflammation hypothesis holds . . . that elevation of cytokines and reactive oxygen species in Keywords Microglia Neuroinflammation Air pollution the brain mediates the deleterious effects of urban air pollution Neurodegenerative disease on the central nervous system (CNS). Studies in human and animal research document that neuroinflammation occurs in response to several inhaled pollutants. Microglia are a prom- Introduction inent source of cytokines and reactive oxygen species in the brain, implicated in the progressive neuron damage in diverse Early research linking ambient 
TI - Outdoor Ambient Air Pollution and Neurodegenerative Diseases: the Neuroinflammation Hypothesis
JF - Current Environmental Health Reports
DO - 10.1007/s40572-017-0142-3
DA - 2017-04-25
UR - https://www.deepdyve.com/lp/springer-journals/outdoor-ambient-air-pollution-and-neurodegenerative-diseases-the-OswOFw17j9
SP - 166
EP - 179
VL - 4
IS - 2
DP - DeepDyve
ER -