TY - JOUR AU - Packer, Milton AB - Editors’ Page European Heart Journal (2025) 46, 685–686 https://doi.org/10.1093/eurheartj/ehae770 The hypothesis: a new article type and platform for iconoclasts in medicine 1,2, Milton Packer * 1 2 Baylor Heart and Vascular Institute, Baylor University Medical Center, 621 North Hall Street, Dallas, TX 75226, USA; and Imperial College, London, UK Received 15 September 2024; accepted 23 October 2024; online publish-ahead-of-print 23 December 2024 prevailing wisdom. Most importantly, the hypothesis must be testable Introduction and falsifiable. An untestable hypothesis is simply an aimless cognitive The scientific method is built on several key elements: the hypothesis, exercise, whereas a falsifiable hypothesis presents a path for the design the analysis, and the synthesis. The hypothesis should precede obser- of specific future studies. vations that yield data that can be analysed; and once the evidence has To be useful, it is not important for the novel hypothesis to be been broken down (i.e. analysed), the findings can be built up again correct. Most useful hypotheses in medicine and science are eventu- (i.e. synthesized) into a conclusion. If there is no hypothesis, then it ally demonstrated to be wrong, and even when it is correct, the val- is difficult to conduct experiments that yield interpretable TI - The hypothesis: a new article type and platform for iconoclasts in medicine JO - European Heart Journal DO - 10.1093/eurheartj/ehae770 DA - 2024-12-23 UR - https://www.deepdyve.com/lp/oxford-university-press/the-hypothesis-a-new-article-type-and-platform-for-iconoclasts-in-OslvH71P4L SP - 685 EP - 686 VL - 46 IS - 8 DP - DeepDyve ER -