TY - JOUR AU - Huisman, T. H. J. AB - February 1975 LETTER S T O TH E EDITOR Dr. Penner's Reply To the Editor: — Mr. Glover is correct in years and overlooked this mistake when pointing out that citrate concentration is proofreading the manuscript. decreased in anemic blood samples. We JOHN A PENNER M D have been making this point for many p f'internal Medicine Professmi De L 0 The University of Michigan Medical Center Received July 22, 1974; accepted for publication Ann Arbor, Michigan 48104 Jul y 22, 1974. Hemoglobin F and Sickle-cell Anemia To the Editor: — In a recent paper it was concept that cells markedly deficient in stated that "There is no doubt that the fetal hemoglobin are more susceptible to presence of Hb-F does interfere with the sickling, while those with higher contents sickling process providing it is present are relatively resistant. with Hb-S in the same cell. However, this RONAL D G. STRAUSS, M.D. is not the case in SS patients and, there­ Children's Hospital Research Foundation fore, increased levels of Hb-F will be Cincinnati, Ohio 45229 beneficial only when the number of Hb- References F-containing erythrocytes is high enough to participate significantly in the oxygen 1. Bertles JF, Milner PFA: TI - The Authors’ Reply JF - American Journal of Clinical Pathology DO - 10.1093/ajcp/63.2.289b DA - 1975-02-02 UR - https://www.deepdyve.com/lp/oxford-university-press/the-authors-reply-Or173Ye7Z8 SP - 289 EP - 289 VL - 63 IS - 2 DP - DeepDyve ER -