TY - JOUR
AU1 - Grain, Audrey
AU2 - Rialland-Battisti, Fanny
AU3 - Chevallier, Patrice
AU4 - Blin, Nicolas
AU5 - Dalle, Jean-Hugues
AU6 - Michel, Gérard
AU7 - Dhédin, Nathalie
AU8 - Peffault de Latour, Regis
AU9 - Pochon, Cécile
AU1 - Yakoub-Agha, Ibrahim
AU1 - Bertrand, Yves
AU1 - Sirvent, Anne
AU1 - Jubert, Charlotte
AU1 - Forcade, Edouard
AU1 - Berceanu, Ana
AU1 - Gandemer, Virginie
AU1 - Schneider, Pascale
AU1 - Bay, Jacques-Olivier
AU1 - Rohrlich, Pierre-Simon
AU2 - Brissot, Eolia
AU2 - Paillard, Catherine
AU2 - Plantaz, Dominique
AU2 - Nguyen Quoc, Stéphanie
AU2 - Gonzales, Fanny
AU2 - Maillard, Natacha
AU2 - Planche, Lucie
AU2 - Baruchel, André
AB - PurposeIn the acute lymphoblastic leukemia (ALL) landscape, adolescents and young adults (AYA) often present high-risk diseases and increased chemotherapy-related toxicity. Studies analyzing the outcomes of AYA after hematopoietic stem cell transplantation (HSCT) are scarce. Our study aimed to compare the outcomes of children and AYA with ALL after HSCT and to determine the factors influencing potential differences.Method891 patients, from the SFGM-TC registry, aged between 1 and 25 years who received HSCT between 2005 and 2012 were included. The outcomes of AYA were compared to the ones of their younger counterparts.ResultsFive-year OS and GRFS were lower in AYA: 53.1% versus 64% and 36% versus 47% (p = 0.0012 and p = 0.007, respectively). WhileCIR was similar in both groups, 5 year-treatment related mortality was higher in AYA: 19% versus 13% (p = 0.04). The lower GRFS in AYA was mainly explained by a higher chronic graft versus host disease (cGvHD) incidence: 32% versus 19% (p < 0.001). Use of peripheral blood stem cells and use of anti-thymoglobulin appeared to be the main factors impacting cGvHD occurrence in AYA.ConclusionAYA have worse outcomes than children after HSCT for ALL because of a greater risk of TRM due to cGvHD. HSCT practices should be questioned in this population.
TI - Hematopoietic stem cell transplantation for acute lymphoblastic leukemia: why do adolescents and young adults outcomes differ from those of children? A retrospective study on behalf of the Francophone Society of Stem Cell Transplantation and Cellular Therapy (SFGM-TC)
JF - Journal of Cancer Research and Clinical Oncology
DO - 10.1007/s00432-022-04021-1
DA - 2023-04-01
UR - https://www.deepdyve.com/lp/springer-journals/hematopoietic-stem-cell-transplantation-for-acute-lymphoblastic-OcGtHriQzY
SP - 1473
EP - 1483
VL - 149
IS - 4
DP - DeepDyve
ER -