TY - JOUR
AU1 - Rigon, Adriana R.
AU2 - Takahashi, R. N.
AB -  The present study evaluated the effects of dimethocaine and procaine, esteratic local anesthetics, on locomotor activity, conditioned place preference and on the elevated plus-maze test of anxiety in mice, behavioral tests believed to be sensitive to cocaine action. Acute administration of dimethocaine (10–40 mg/kg, IP) significantly increased locomotor activity and time spent on the drug-paired side and reduced the relative number of entries and time spent on the open arms of the plus-maze in mice. Procaine (20–50 mg/kg, IP) failed to affect these responses. These data demonstrate the locomotor stimulant, reinforcing and anxiogenic actions of dimethocaine similar to those reported for cocaine in animals. In addition, these findings support a role for dopaminergic activity, rather than local anesthetic action, in the behavioral effects caused by dimethocaine.
TI - Stimulant activities of dimethocaine in mice: reinforcing and anxiogenic effects
JF - Psychopharmacology
DO - 10.1007/s002130050093
DA - 1996-10-18
UR - https://www.deepdyve.com/lp/springer-journals/stimulant-activities-of-dimethocaine-in-mice-reinforcing-and-ORYLqCqbtn
SP - 323
EP - 327
VL - 127
IS - 4
DP - DeepDyve
ER -