TY - JOUR
AU - Smith, Mark R.
AB - V Headingalidation Column Calibration transfer in pharmaceutical near infrared spectroscopy Mark R. Smith (Pharmaceutical Analytical Sciences Group (PASG), Near-Infrared Subgroup) (Centre for Pharmaceutical Analysis, The School of Pharmacy, University of London, 29/39 Brunswick Square, London WC1N 1AX, UK, E-mail: mark.smith@ulsop.ac.uk) spectroscopic assays for the active in a simple procedure in which the spec- Introduction intact pharmaceutical tablets due to tral offset is determined between two associated difficulties (i.e. interference instruments using a common set of In our experience, one of the major from other components and physical samples, with the difference then used obstacles to the widespread implemen- affects resulting from the use of solid to adjust spectra measured on the tation of near infrared (NIR) spectros- dosage forms) and the applicability of transfer instrument to resemble as if copy within the pharmaceutical industry such methods to industry. Where it has scanned on the master instrument. We is the limited transferability of quantita- been found necessary to apply correc- chose to use backward standardisa- tive methods. A significant amount of tion methods, the emphasis is placed tion as it is advantageous not to have research has been carried out into cali- on avoiding complicated chemometrics to alter the calibration 
TI - Calibration Transfer in Pharmaceutical near Infrared Spectroscopy
JF - NIR News
DO - 10.1255/nirn.796
DA - 2004-12-01
UR - https://www.deepdyve.com/lp/sage/calibration-transfer-in-pharmaceutical-near-infrared-spectroscopy-OPF38FeKhV
SP - 13
EP - 15
VL - 15
IS - 6
DP - DeepDyve
ER -