TY - JOUR
AU - SMITH, RICHMOND W.
AB - Abstract During the past year, new derivatives of hydrocortisone have been made available. One of these compounds, fludrocortisone (9a-fluorohydrocortisone), was first synthesized by Fried and Sabo1 at the laboratories of the Squibb Institute of Medical Research. It is made by the insertion of the fluorine atom at the 9a position of hydrocortisone acetate. Ointments and lotions containing this drug (hereafter referred to as fludrocortisone) have been evaluated by a number of dermatologists.* Witten and associates4 and Robinson5 are the only investigators to date who have published on this subject. It is the consensus that fludrocortisone † is a potent topical therapeutic agent for the treatment of conditions which respond to hydro-cortisone ointment and lotion. It appears that 0.1%-0.25% fludrocortisone ointment and lotion have at least the same degree of therapeutic efficacy as the 1%-2.5% hydrocortisone preparations; for the local treatment of a References 1. References 2 and 3. 2. Fludrocortisone ointment and/or lotion (0.1%, 0.2%, and 0.25%) are now available commercially from three pharmaceutical houses. 3. References 6 and 7. 4. Florinef (Squibb) ointment and lotion were supplied to us by Dr. Harvey Blank of the Squibb Institute of Medical Research, New Brunswick, N. J. 5. Cormia, F.: Personal communication to the authors. 6. Lerner, A. B.: Personal communication to the authors. 7. Fried, J., and Sabo, E. F.: 9-Alpha-Fluoro Derivatives of Cortisone and Hydrocortisone , J. Am. Chem. Soc. 76:1455, 1954.Crossref 8. Wright, E. T.; Graham, J. H.; Newcomer, V. D., and Sternberg, T.: 9a-Fluorohydrocortisone Acetate in the Treatment of Various Inflammatory Dermatoses , A. M. A. Arch. Dermat. 72:69, 1955.Crossref 9. Fitzpatrick, T. B.; Griswold, H. C., and Hicks, J. H.: Sodium Retention and Edema from Percutaneous Absorption of 9-alpha-Fluorohydrocortisone Acetate Lotion and Ointment, to be published. 10. Witten, V. H.; Sulzberger, M. B.; Zimmerman, E. H., and Shapiro, A. J.: A Therapeutic Assay of Topically Applied 9a-Fluorohydrocortisone in Selected Dermatoses , J. Invest. Dermat. 24:1, 1955. 11. Robinson, R. C. V.: Use of Fludrocortisone Acetate in Dermatoses , J. A. M. A. 157:1300, 1955.Crossref 12. Ward, L. E.; Polley, H. F.; Slocumb, C. H.; Hench, P. S.; Mason, H. L.; Mattox, V. R., and Power, M. H.: The Effects of Aldosterone (Electrocortin) and of 9a-Fluorohydrocortisone Acetate on Rheumatoid Arthritis: Preliminary Report , Proc. Staff. Meet., Mayo Clin. 29:649, 1954. 13. Goldfien, A.; Laidlaw, J. C.; Haydan, N. A.; Renold, A. E., and Thorn, G. W.: Fluorohydrocortisone and Chlorohydrocortisone, Highly Potent Derivatives of Compound F , New England J. Med. 252:415, 1955.Crossref 14. Clark, L. C., Jr., and Thompson, H. L.: Determination of Creatine and Creatinine in Urine , Analyt. Chem. 21:1218, 1949.Crossref 15. Smith, R. W., Jr.; Mellinger, R. C., and Patti, A. A.: Modification of the Reddy Procedure for 17-Hydroxycorticoids in Urine , J. Clin. Endocrinol. 14:236, 1954.Crossref 16. Reddy, W. J.; Jenkins, D., and Thorn, G. W.: Estimation of 17-Hydroxycorticoids in Urine , Metabolism 1:511, 1952. 17. Klendshoj, N. C.; Felstein, M., and Sprague, B. A.: Determination of 17-Ketosteroids in Urine , J. Clin. Endocrinol. 13:922, 1953.Crossref 18. Drekter, F. J.; Hersler, A.; Scisin, G. R.; Stern, S.; Pearson, S., and McGavack, T. H.: The Determination of Urinary Steroids: I. The Preparation of Pigment-Free Extracts and a Simplified Procedure for the Estimation of Total 17-Ketosteroids , J. Clin. Endocrinol. 12:55, 1952.Crossref 19. Smith, C. C.: Eosinophilic Response After Inunction of Hydrocortisone Ointment , A. M. A. Arch. Dermat. & Syph. 68:50-53, 1953.
TI - Studies on the Percutaneous Absorption of Fludrocortisone
JF - A.M.A. Archives of Dermatology
DO - 10.1001/archderm.1955.03730340011003
DA - 1955-10-01
UR - https://www.deepdyve.com/lp/american-medical-association/studies-on-the-percutaneous-absorption-of-fludrocortisone-OE9AJUa7xg
SP - 313
EP - 327
VL - 72
IS - 4
DP - DeepDyve
ER -