TY - JOUR
AU1 - Patil, Shripad M
AU2 - Bedre, Ashwini V
AU3 - Gade, Vilas B
AU4 - Jopale, Manohar K
AB - A novel, green, catalyst-free, and efficient method has been developed for the one-pot reductive amination of carbonyl compounds using sodium borohydride. This method has performed reductive amination on various functionalized amines and aldehydes, including aliphatic, aromatic, and heteroaromatic compounds. The reductive amination of the carbonyl compounds occurred in a single step without any side reaction. The key benefits of this technique included its easiness, greener protocol, quick transformation, variety of substrates, high yield, metal-free, and solvent recyclability. This helps to make the procedure practical, affordable, and biodegradable.Graphical abstractA novel, green, catalyst-free, and efficient method has been developed for one-pot reductive amination of carbonyl compounds using sodium borohydride. This method has performed reductive amination on various functionalized amines and aldehydes, including aliphatic, aromatic, and hetero-aromatic ones. The reductive amination of the carbonyl compounds occurred in a single step without any side reaction. The key benefits of this technique included its easiness, greener protocol, quick transformation, variety of substrates, outstanding yield, metal-free, and solvent recyclability. This helps to make the procedure practical, affordable, and biodegradable. In this work, we studied electron-donating, electron-withdrawing, aliphatic, heterocyclic, and chiral amines used in the reaction.[graphic not available: see fulltext]
TI - Metal-free, an effective and one-pot protocol for the reductive amination of aldehydes using glycerol as a green solvent
JF - "Journal of Chemical Sciences"
DO - 10.1007/s12039-023-02172-3
DA - 2023-05-29
UR - https://www.deepdyve.com/lp/springer-journals/metal-free-an-effective-and-one-pot-protocol-for-the-reductive-O9wtBp9Z0T
VL - 135
IS - 2
DP - DeepDyve
ER -