TY - JOUR
AU1 - Koz'minykh, V.
AU2 - Igidov, N.
AU3 - Koz'minykh, E.
AU4 - Kolla, V.
AU5 - Drovosekova, L.
AU6 - Semenova, Z.
AU7 - Novoselova, G.
AU8 - Andreichikov, Yu.
AB - SYNTHESIS AND BIOLOGICAL ACTIVITY OF 2-SUBSTITUTED 5-ARYL-2,3- DIHYDRO-3-FURANONES UDC 615.31:547.724].012.1.07 V. O. Koz'minykh, N. M. Igidov, E. N. Koz'minykh, V. E. Kolla, L. P. Drovosekova, Z. N. Semenova, G. V. Novoselova, and Yu. S. Andreichikov A previous work has shown that the 3-furanones, and specifically the 5-aryl-2,3-di- hydro-3-furanones, display some potential in the search for compounds that exhibit a wide range of biological activity [7]. With this in mind we obtained the 5-aryl-2-(arylamino) alkoxycarbonylmethyl-2,3-dihydro-3-furanones (I-V) by reacting 2-alkoxycarbonylmethylene-5- aryl-2,3-dihydro-3-furanones with arylamines (method A) [i, 2]. Addition of 2~4-dinitro- phenylhydrazine (method B) or the hydrazones of benzaldehyde and p-nitrobenzaldehyde (method C) at the 2-exoethylene bond of the 5-aryl-2-methoxycarbonylmethylene-2,3-dihydro-3-furanones yielded the structurally-similar 5-aryl-2-(hydrazino)methoxycarbonylmethyl-2,3-dihydro-3- furanones (VI-XIII) [5]. H O II O I t /'x, / /NHX C,03R ' COOiN I-,~ r R~=H(I--III, VI, XI, XlI), CH3(VII, XIIl), CH30(IV, VIII), Br(IX), CI(V, X); R2=CH3(I, I1, IV--XIII), C2H~(ItI); X=C6Hs(I); 4-CH3C6H4(II, V), 4-CH3OC6H4(III, IV), 2,4- (NO2) 2CoHsNH (VI--X), C6HsCH=N (XI, XIII), 4-NO2C6H4CH= N (XII). The physicochemical and spectral characteristics of 3-furanones I-IV are cited in works [i, 2] and those of compounds V-XIII are given in Table I. The structure of the synthesized substances was corroborated by IR, PMR, MS, and elemental analysis. The IR 
TI - Synthesis and biological activity of 2-substituted 5-aryl-2,3-dihydro-3-furanones
JF - Pharmaceutical Chemistry Journal
DO - 10.1007/BF00766453
DA - 2004-11-23
UR - https://www.deepdyve.com/lp/springer-journals/synthesis-and-biological-activity-of-2-substituted-5-aryl-2-3-dihydro-O7BRR2SWcH
SP - 142
EP - 146
VL - 26
IS - 2
DP - DeepDyve
ER -