TY - JOUR AU - Lins-Kusterer, Liliane AB - Gender, as a social determinant of health, can favor social and health inequalities that compromise the health-related quality of life (HRQOL) in people living with HIV/AIDS (PLWHA). This study aims to compare HRQOL in women and men with HIV in Brazil and identify factors associated with their physical and mental health. Two hundred eighteen men and 101 women with HIV completed a sociodemographic and clinical questionnaire, the 36-item Short Form Health Survey (SF-36v2), the HIV/AIDS-Targeted Quality of Life (HAT-QOL), and the WHOQOL-HIV BREF. HRQOL scores were compared with the Mann-Whitney U test, and multiple linear regression analyses were used to identify factors related to Physical and Mental Health (PCS and MCS of SF-36v2). Women had worse HRQOL than men in all three instruments. Models for Physical Health (Women: R2 = 0.56, p < .001; Men: R2 = 0.552, p < .001) and Mental Health (Women: R2 = 0.602, p < .001; Men: R2 = 0.600, p < .001) showed gender-related differences. Overall Function (Women: Beta = 0.496; Men: Beta = 0.387) and Level of Independence (Women: Beta = 0.375; Men: Beta = 0.305) were the domains that best predicted Physical Health in both genders. Environment in women (Beta = − 0.289) and Psychological in men (Beta = 0.372) were the domains that best predicted Mental Health. Significant HRQOL and physical and mental health differences were associated with gender in PLWHA in Brazil. TI - Health-related quality of life: gender differences in people living with HIV/AIDS JO - Current Psychology DO - 10.1007/s12144-023-04876-8 DA - 2024-09-01 UR - https://www.deepdyve.com/lp/springer-journals/health-related-quality-of-life-gender-differences-in-people-living-O3s1cO5973 SP - 27295 EP - 27305 VL - 43 IS - 33 DP - DeepDyve ER -