TY - JOUR
AU - Hughes, Robert
AB - A number of valuable new synthetic strategies, such as the triazene‐driven biaryl ether synthesis, have been developed during the total synthesis of vancomycin (1). Modern catalytic asymmetric reactions were employed for the construction of the required amino acid building blocks, which were then assembled to the appropriate peptide fragments, whose cyclization in the order C‐O‐D→AB/C‐O‐D→AB/C‐O‐D‐E led to framework of the vancomycin aglycon (2). Sequential attachment of the required sugar moieties onto a suitably protected aglycon derivative, followed by deprotection, allowed the stereoselective total synthesis of the glycopeptide antibiotic vancomycin (1).
TI - Total Synthesis of Vancomycin—Part 3: Synthesis of the Aglycon
JO - Chemistry - A European Journal
DO - 10.1002/(SICI)1521-3765(19990903)5:9<2622::AID-CHEM2622>3.0.CO;2-T
DA - 1999-03-03
UR - https://www.deepdyve.com/lp/wiley/total-synthesis-of-vancomycin-part-3-synthesis-of-the-aglycon-NecGo0tG2Y
SP - 2622
EP - 2647
VL - 5
IS - 9
DP - DeepDyve
ER -