TY - JOUR
AU - Koh, Naoki
AB - Abstract To investigate the role of increased polyol pathway activity and hemodynamic deficits in the pathogenesis of diabetic retinopathy in non-insulin-dependent diabetes mellitus (NIDDM), Otsuka Long-Evans Tokushima fatty (OLETF) rats, an animal model of human NIDDM, were given water with or without 30% sucrose and some of them were fed laboratory chow containing 0.03% cilostazol, an anticoagulant, or 0.05% 5-(3-thienyl)tetrazol-1-yl acetic acid monohydrate (TAT), an aldose reductase inhibitor, for 8 wk. Long-Evans Tokushima Otsuka (LETO) rats were used as nondiabetic controls. The peak latencies of oscillatory potentials of the electroretinogram in sucrose-fed OLETF rats were significantly prolonged compared with those in OLETF rats without sucrose feeding and LETO rats. There was a marked increase in platelet aggregability and a significant decrease in erythrocyte 2,3-diphosphoglycerate in sucrose-fed OLETF rats. Cilostazol significantly improved these parameters without changes in retinal levels of sorbitol and fructose. TAT, however, ameliorated all of these parameters. These findings confirm that the sucrose-fed OLETF rat is a useful animal model of retinopathy in human NIDDM and suggest that cilostazol improved diabetic retinopathy by modifying vascular factors, not by altering polyol pathway activity. Otsuka Long-Evans Tokushima fatty rats cilostazol platelet aggregation red blood cell 2,3-diphosphoglycerate polyol pathway 5-(3-thienyl) tetrazol-1-yl acetic acid monohydrate Footnotes Address for reprint requests: N. Hotta, The Third Dept. of Internal Medicine, Nagoya Univ. School of Medicine, 65 Tsuruma-cho, Showa-ku, Nagoya 466, Japan. Copyright © 1997 the American Physiological Society
TI - Electroretinogram in sucrose-fed diabetic rats treated with an aldose reductase inhibitor or an anticoagulant
JO - AJP - Endocrinology and Metabolism
DA - 1997-11-01
UR - https://www.deepdyve.com/lp/the-american-physiological-society/electroretinogram-in-sucrose-fed-diabetic-rats-treated-with-an-aldose-NTBWwuaQSi
VL - 273
IS - 5
DP - DeepDyve
ER -