TY - JOUR
AU - Paganelli, Giovanni
AB - Purpose We studied the usefulness of Ga-prostate-specific membrane antigen (PSMA) PET/CT for detecting relapse in a prospective series of patients with biochemical recurrence (BCR) of prostate cancer (PCa) after radical treatment. Methods Patients with BCR of PCa after radical surgery and/or radiotherapy with or without androgen-deprivation therapy were included in the study. Ga-PSMA PET/CT scans performed from the top of the head to the mid-thigh 60 min after intravenous injection of 150 ± 50 MBq of Ga-PSMAwere interpreted by two nuclear medicine physicians. The results were correlated with prostate-specific antigen (PSA) levels at the time of the scan (PSApet), PSA doubling time, Gleason score, tumour stage, postsurgery tumour residue, time from primary therapy to BCR, and patient age. When available, Ga-PSMA PET/CT scans were compared with negative F-choline PET/CT scans routinely performed up to 1 month previously. Results From November 2015 to October 2017, 314 PCa patients with BCR were evaluated. Their median age was 70 years (range 44–92 years) and their median PSApet was 0.83 ng/ml (range 0.003–80.0 ng/ml). Ga-PSMA PET/CT was positive (one or more suspected PCa lesions detected) in 197 patients (62.7%). Lesions limited to the pelvis, i.e. the prostate/prostate bed and/or pelvic lymph nodes (LNs), 
TI - 68Ga-PSMA PET/CT in patients with recurrent prostate cancer after radical treatment: prospective results in 314 patients
JF - European Journal of Nuclear Medicine and Molecular Imaging
DO - 10.1007/s00259-018-4067-3
DA - 2018-06-19
UR - https://www.deepdyve.com/lp/springer-journals/68ga-psma-pet-ct-in-patients-with-recurrent-prostate-cancer-after-NHDfCH0Wyd
SP - 2035
EP - 2044
VL - 45
IS - 12
DP - DeepDyve
ER -