TY - JOUR
AU - Aikawa, Elena
AB - Graphical AbstractGraphical abstractCalcific aortic valve disease (CAVD) results from a complex physiological microenvironment and multifaceted interplay amongst a number of putative initiators and drivers of disease. Multi-omics enables a holistic assessment of molecular drivers of CAVD via quantitation of the (epi)genome, transcriptome, proteome, and metabolome at both a bulk and single-cell level. Integration of multiple omics modalities facilitates the identification of novel, subtle, or cross-layer molecules and interactions. Target prioritization via systems biology precedes drug development and eventual pharmaceutical alternatives to surgical aortic valve replacement or transcatheter aortic valve replacement.
TI - Calcific aortic stenosis: omics-based target discovery and therapy development
JO - European Heart Journal
DO - 10.1093/eurheartj/ehae829
DA - 2024-12-04
UR - https://www.deepdyve.com/lp/oxford-university-press/calcific-aortic-stenosis-omics-based-target-discovery-and-therapy-N70ia83grQ
SP - 620
EP - 634
VL - 46
IS - 7
DP - DeepDyve
ER -