TY - JOUR
AU - HYYTIÄ,, P.
AB - Abstract To study the role of genetic factors in the effects of prenatal alcohol exposure on behaviour, dams of two rat lines developed to differ in voluntary alcohol intake, alcohol-preferring (AA) and alcohol-avoiding (ANA) rats were given a 5–10% alcohol solution mixed with a 1% sucrose solution as a sole drinking liquid throughout gestation. Sleep-wake behaviour of the offspring was studied at the ages of 7, 14 and 20 days, using a movement-sensitive mattress. In ANA rats, sleep recordings showed that prenatal alcohol exposure increased the percentage of waking but decreased the percentage of active sleep. Sleep-wake behaviour of the AA rats was not affected by alcohol exposure in utero . Prenatal alcohol exposure did not change open field behaviour in 1 month old rats, except that the alcohol-exposed AA rats' defaecation was decreased. When rats were 3 months old, voluntary intake of 10% ( v/v ) alcohol increased for alcohol-exposed ANA rats and decreased for alcohol-exposed AA rats as compared to the controls. The results indicate that AA rats may compensate for the effects of prenatal alcohol exposure on behaviour, whereas offspring of the alcohol-exposed ANA dams suffer from severe behavioural disturbances. These Findings further suggest that genetic factors are responsible for the differences in the susceptibility of rat foetuses to alcohol-induced long-term effects on behaviour. This content is only available as a PDF. © 1987 Medical Council on Alcoholism
TI - EFFECT OF PRENATAL ALCOHOL EXPOSURE ON NEONATAL SLEEP-WAKE BEHAVIOUR AND ADULT ALCOHOL CONSUMPTION IN THE AA AND ANA RAT LINES
JO - Alcohol and Alcoholism
DO - 10.1093/oxfordjournals.alcalc.a044703
DA - 1987-01-01
UR - https://www.deepdyve.com/lp/oxford-university-press/effect-of-prenatal-alcohol-exposure-on-neonatal-sleep-wake-behaviour-Mbop596BF2
SP - 231
EP - 240
VL - 22
IS - 3
DP - DeepDyve
ER -