TY - JOUR
AU - CZERNICHOW,, PAUL
AB - Abstract The effect of hypothyroidism on pancreatic TRH (P-TRH) and P-TRH-degrading activity (P-TRH-DA) was studied in adult rats. Hypothyroidism was induced in three groups during 4, 6, or 9 weeks by propylthiouracil (PTU) in drinking water and a low iodine diet (LID). Another group received PTU-LID for 6 weeks, followed by 5 weeks on a normal diet to restore euthyroidism. A possible toxic effect of PTU per se was eliminated by treating one control group with PTU and T3. P-TRH and TRH-DA were measured by specific RIA. In the hypothyroid groups, P-TRH concentrations (mean ± sem) were increased 10-fold (6.95 ± 2.09; 5.51 ± 1.3; 9.79 ± 3.3 pg/(mg-100. g BW), respectively, with a control value of 0.55 ± 0.39, P < 0.01). This increase was reversible, as shown by the group on PTU-LID followed by a normal diet (0.58 ± 0.39, NS). p-TRH-DA present in the control group was decreased after 4 weeks of PTU-LID treatment and totally abolished after 6 and 9 weeks of PTU-LID treatment. In conclusion, these results suggest that thyroid status modulates P-TRH concentrations. This effect may be due to the disappearance of the TRH-DA in response to hypothyroidism. P-TRH stores may be regulated by the enzyme(s) involved in P-TRH-DA. (Endocrinology114: 1334, 1984) This content is only available as a PDF. Copyright © 1984 by The Endocrine Society
TI - Hypothyroidism Increases Pancreatic Thyrotropin-Releasing Hormone Concentrations in Adult Rats
JF - Endocrinology
DO - 10.1210/endo-114-4-1334
DA - 1984-04-01
UR - https://www.deepdyve.com/lp/oxford-university-press/hypothyroidism-increases-pancreatic-thyrotropin-releasing-hormone-MUikZCcVue
SP - 1334
EP - 1337
VL - 114
IS - 4
DP - DeepDyve
ER -