TY - JOUR
AU - Sachs, David H.
AB - Two animal models are described which are currently being studied in this laboratory in attempts to induce specific transplantation tolerance across major histocompatibility barriers. One model involves the use of minature swine selectively inbred at the MHC. Exposure of these animals to a vascular graft genetically identical to the recipient at class II was found to be sufficient to induce long‐term, specific tolerance to both class I and minor antigens in about one‐third of animals. Tolerance induction in this situation appears to be an active immunologic phenomenon involving a suppressive arm of the immune response. In the second model, induction of mixed lymphohematopoietic chimerism in mice was found to produce specific transplantation tolerance toward the allogeneic bone marrow donor. The mixed chimerism has been induced either by lethal irradiation and reconstitution with mixtures of syngeneic and allogeneic bone marrow, or by treatment with monoclonal antibodies followed by sublethal irradiation and administration of allogeneic bone marrow. Because the latter preparative regimen is non‐lethal, it may be clinically applicable for the induction of specific tolerance to human organ transplants.
TI - Antigen‐specific transplantation tolerance
JO - Clinical Transplantation
DO - 10.1111/j.1399-0012.1990.tb00208.x
DA - 1990-04-01
UR - https://www.deepdyve.com/lp/wiley/antigen-specific-transplantation-tolerance-MTL6pUuyM2
SP - 78
EP - 81
VL - 4
IS - 2
DP - DeepDyve
ER -