TY - JOUR
AU1 - Anaissie, Elias, J.
AU2 - Kontoyiannis, Dimitrios, P.
AU3 - Vartivarian,, Shahe
AU4 - Kantarjian, Hagop, M.
AU5 - O&apos
AU6 - Brien,, Susan
AU7 - Giralt, Sergio, A.
AU8 - Andersson, Borge, S.
AU9 - Karl,, Cynthia
AU1 - Champlin, Richard, E.
AU1 - Bodey, Gerald, P.
AB - Abstract Fungal infections are the most common infectious cause of death among patients with hematologic malignancies. Conventional antifungal agents have limited activity and a narrow therapeutic index. In an open-label study we assessed the activity of an oral triazole, SCH 39304, in the treatment of refractory life-threatening mold infections in 50 patients with cancer, most of whom had previously received amphotericin B and/or fluconazole. SCH 39304 was given at a daily dose of 200–400 mg for a median of 8 weeks. The overall rate of response was 79% among 34 evaluable patients, with a complete response in 22 instances and a partial response in 5. Some patients responded despite persistent, profound immunosuppression. Three patients developed relapses, and two developed fungal superinfections. SCH 39304 was well tolerated. We conclude that oral triazoles such as SCH 39304 may represent effective and safe treatment of mold infections in immunosuppressed patients, at least after standard antifungal chemotherapy. Unfortunately, the carcinogenic potential of SCH 39304 in animals has precluded its development. Our hope is that analogues with similar efficacy but without carcinogenic potential can be developed. This content is only available as a PDF. © 1993 by The University of Chicago
TI - Effectiveness of an Oral Triazole for Opportunistic Mold Infections in Patients with Cancer: Experience with SCH 39304
JF - Clinical Infectious Diseases
DO - 10.1093/clinids/17.6.1022
DA - 1993-12-01
UR - https://www.deepdyve.com/lp/oxford-university-press/effectiveness-of-an-oral-triazole-for-opportunistic-mold-infections-in-MRNPeEhTxS
SP - 1022
EP - 1031
VL - 17
IS - 6
DP - DeepDyve
ER -