TY - JOUR
AU - Laven, J.S.E.
AB - STUDY QUESTIONAre first trimester trophoblast volume (TV) and placental bed vascular volume (PBVV) different in IVF or IVF/ICSI pregnancies in comparison with spontaneously conceived pregnancies?SUMMARY ANSWERAny possible abnormal placentation in IVF or IVF/ICSI pregnancies in comparison with spontaneously conceived pregnancies is not detected by a difference in PBVV or TV at an early gestational age (GA).WHAT IS KNOWN ALREADYAssisted reproductive technology pregnancies have been associated with an increased risk of placenta-related adverse pregnancy outcomes. It is unclear whether these effects originate from infertility or from the technique itself.STUDY DESIGN, SIZE, DURATIONWe performed a retrospective cohort study in which 154 pregnant patients qualified for participation.PARTICIPANTS/MATERIALS, SETTING, METHODSOut of 154 pregnant patients, 84 conceived spontaneously and 70 conceived after IVF or IVF/ICSI. We determined the TV at 10 weeks GA by Virtual Organ Computer-aided AnaLysis measuring application and the PBVV at 12 weeks GA by the virtual reality operating system of BARCO I-Space in both subgroups. The investigators were blinded to the mode of conception during the measurements. Analysis was limited to singleton pregnancies with only one sac ever detectable.MAIN RESULTS AND THE ROLE OF CHANCEThere were no differences in TV (mean 42.7, SD 15.9 versus mean 41.2, SD 13.9, P = 0.70) and PBVV (mean 27.6, SD 16.9 versus mean 24.8, SD 19.9, P = 0.20) between IVF or IVF/ICSI pregnancies and spontaneously conceived pregnancies. There was a significant correlation between TV and PBVV (rs = 0.283, P = 0.004).LIMITATIONS, REASONS FOR CAUTIONThe limitations of the present study concern the small size of the study groups.WIDER IMPLICATIONS OF THE FINDINGSIVF or IVF/ICSI does not seem to be associated with abnormal placentation.STUDY FUNDING/COMPETING INTEREST(S)This study was financially supported by the Erasmus Trustfonds, the Meindert de Hoop foundation and the Fonds NutsOhra. No competing interests are declared.
TI - First trimester trophoblast and placental bed vascular volume measurements in IVF or IVF/ICSI pregnancies
JO - Human Reproduction
DO - 10.1093/humrep/deu273
DA - 2014-12-21
UR - https://www.deepdyve.com/lp/oxford-university-press/first-trimester-trophoblast-and-placental-bed-vascular-volume-MO5YfndeP4
SP - 2644
EP - 2649
VL - 29
IS - 12
DP - DeepDyve
ER -