TY - JOUR
AU - Alexander, E. R.
AB - Thirty five female Cebus albifrons monkeys (16 adolescents and 19 adults) were infected vaginally with herpes simplex virus (HSV) type 2. Fifteen developed spontaneous recurrent genital HSV infections. All 35 were killed for study eight to 12 months after primary infection, and tissue from the vagina, cervix, uterus, ovary, paracervical autonomic plexus, and lumbosacral dorsal root ganglia was examined for latent HSV. HSV type 2 was recovered from the lumbosacral dorsal root ganglia of eight animals. Host age was the most important variable influencing viral latency; 69% of adolescents and 42% of adults had latent HSV type 2 infections. Animals that developed latent infections were significantly easier to infect, shed virus during the primary infection significantly longer, and had more severe primary disease than those who did not become latently infected.
TI - A Primate Model for Age and Host Response to Genital Herpetic Infection: Determinants of Latency
JO - The Journal of Infectious Diseases
DO - 10.1093/infdis/143.4.554
DA - 1981-04-01
UR - https://www.deepdyve.com/lp/oxford-university-press/a-primate-model-for-age-and-host-response-to-genital-herpetic-MMSEyKdSyw
SP - 554
EP - 557
VL - 143
IS - 4
DP - DeepDyve
ER -