TY - JOUR
AU - Holt, P.J.A.
AB - Clinical and hlxperimenial Dermatology 1993; 18: 291 294. Correspondence How to reduce tbe discomfort caused by l()cal anaesthetics beneficial effects may derive from either increased fragility of the stratum corneum, as previously suggested,' or reflect altered keratino- SiK, Dr Arndt correctlv reminds us that several factors nia> influence cyte differentiation,^ ihe degree n(" discomfort caused by local anaesthetic injections, Although hlack hair\ longue is a henign condition, it is often including: the depth of the injection; rate of injection; and needle remarkahh resistant to treatment and frequently causes the patient gauge,' However, the choice of local anaesthetic agent is also considerable distress. Despite their toxicity. retitioids may be an extremel) imporiant. effective treatment for this condition. We investigated possible causes ofthe discotnfort in 32 individuals by means of comparing paired injections of uniform depth and rate, Guy's Hospital J.M.MCGRF.CIOR using 27-gauge needles.^ In all 32 individuals injeciion of 1%, London, UK R.J.HAY lignocaine was more painful ihan 0 5% lignocaine, Lignocaine with References adrenaline I in 200 000 was more painful than plain lignocaine, and the addition of sodium metabisulphite (the aniioxidant present in 1. l.angtry JA.A, Carr MM, Steele MC, Ivu FA, Topical treiinoin: ii new commercial adrenalized 
TI - How to reduce the discomfort caused by local anaesthetics
JF - Clinical and Experimental Dermatology
DO - 10.1111/j.1365-2230.1993.tb02193.x
DA - 1993-05-01
UR - https://www.deepdyve.com/lp/oxford-university-press/how-to-reduce-the-discomfort-caused-by-local-anaesthetics-MB3LteVoVh
SP - 291
EP - 291
VL - 18
IS - 3
DP - DeepDyve
ER -