TY - JOUR
AU1 - Baker, Simon C.
AU2 - Rohman, Geraldine
AU3 - Hinley, Jennifer
AU4 - Stahlschmidt, Jens
AU5 - Cameron, Neil R.
AU6 - Southgate, Jennifer
AB - Flexible, strong scaffolds were created by crosslinking PCL with 1,6‐hexamethylenediisocyanate, using paraffin beads as a porogen. Particulate leaching generated homogeneous scaffolds with interconnected spherical pores of 5–200 µm. Subcutaneous implantation in rats for 3 months resulted in minimal scaffold resorption and a non‐inflammatory regenerative host response, with complete infiltration by alternatively‐activated CD68+ macrophages. In addition, scaffolds were populated extensively along microfractures by a stromal matrix, which was highly vascularised and contained a subset of stromal cells that expressed the anti‐inflammatory CD163 antigen. Such microfractures may be an important physical feature for directing stromal integration and vascularisation events.
TI - Cellular Integration and Vascularisation Promoted by a Resorbable, Particulate‐Leached, Cross‐Linked Poly( ε ‐caprolactone) Scaffold
JF - Macromolecular Bioscience
DO - 10.1002/mabi.201000415
DA - 2011-05-12
UR - https://www.deepdyve.com/lp/wiley/cellular-integration-and-vascularisation-promoted-by-a-resorbable-M7uxDjxGmc
SP - 618
EP - 627
VL - 11
IS - 5
DP - DeepDyve
ER -