TY - JOUR
AU - Nozawa, Ippei
AB - A convenient sequence for the preparation of 3‐alkylidene‐2,3‐dihydro‐1H‐isoindol‐1‐imine derivatives 6 has been developed. Thus, 2‐(1‐azidoalkyl)benzonitriles 2, readily accessible from 2‐alkylbenzonitriles, are allowed to react with NaH in DMF at 0° to room temperature to generate [1‐(2‐cyanophenyl)alkylidene]aminide intermediates 3, of which cyclization and the subsequent rearrangement, followed by alkylation with alkyl halides, affords 2‐substituted 1‐alkylidene‐2,3‐dihydro‐1H‐isoindol‐2‐imines 6 in generally moderate yields.
TI - Synthesis of 2‐Substituted 3‐Alkylidene‐2,3‐dihydro‐1H‐isoindol‐1‐imines through Cyclization of [1‐(2‐Cyanophenyl)alkylidene]aminide Intermediates Generated from the Reaction of 2‐(1‐Azidoalkyl)benzonitriles with NaH
JF - Helvetica Chimica Acta
DO - 10.1002/hlca.201400261
DA - 2014-12-01
UR - https://www.deepdyve.com/lp/wiley/synthesis-of-2-substituted-3-alkylidene-2-3-dihydro-1h-isoindol-1-LoB8prPk8Z
SP - 1624
EP - 1629
VL - 97
IS - 12
DP - DeepDyve
ER -