TY - JOUR
AU - J. A. King , D. J. Lush , and J. C. Fray
AB -  King, Jean A., David J. Lu, and J. C. S. Fray. Regulation of renin processing and secretion: chemiosmotic control and novel secretory pathway. Am. J. Physiol. 265 (Cell Physiol. 34): C305-C320, 1993.-The reninangiotensin-aldosterone system (RAAS) plays an important role in cardiovascular and electrolyte regulation in health and disease. Juxtaglomerular cells in the kidney regulate endocrine RAAS by physiologically controlling conversion of prorenin and secretion of renin. The classical baroceptor, neurogenic, and macula densa mechanisms regulate renin expression at the cellular level by Ca2+, adenosine 3’,5’-cyclic monophosphate (CAMP), and chemiosmotic forces (K+, Cl-, and water flux coupled to H+ movement). The baroceptor mechanism (through Ca2+) activates K+ and Cl- channels in the surface membrane and deactivates a KCl-H+ exchange chemisomotic transporter in the secretory granular membrane. The neurogenic mechanism (through CAMP) promotes prorenin processing to renin. The macula densa mechanism (through K+ and Cl-) involves the processing of prorenin to renin. Ca 2+, by inhibiting the KCl-H+ exchange transporter, prevents secretory granules from engaging in chemiosmotically mediated exocytosis. CAMP, on the other hand, by stimulating H+ influx, provides the acidic granular environment for prorenin processing to renin. It is concluded that, in the presence of a favorable chemiosmotic environment, 
TI - Regulation of renin processing and secretion: chemiosmotic control and novel secretory pathway
JO - AJP - Cell Physiology
DA - 1993-08-01
UR - https://www.deepdyve.com/lp/the-american-physiological-society/regulation-of-renin-processing-and-secretion-chemiosmotic-control-and-LbHCJiSdfs
VL - 265
IS - 
DP - DeepDyve
ER -