TY - JOUR
AU - CRAWFORD, MICHAEL A
AB - British Medical Bulletin (1983) Vol. 39, No. 3, pp. 210-213 ESSENTIAL FATTY ACIDS AND THEIR PROSTANOID DERIVATIVES M A Crawford Sjovali, 1957). Quite separately, knowledge of the EFA grew; the physiologists described a variety of deficiency symptoms associ- ated with a fat deficiency, including testicular atrophy, and in- creased permeability in the skin and cell membranes. Both linoleic BACKGROUND TO ESSENTIAL FATTY and a-linolenic acids supported growth in fat-deficient rats and were considered to possess EFA activity. However, a-linolenic acid ACIDS AND THEIR PROSTANOID appeared to have functions similar to linoleic acid but was less DERIVATIVES active; hence linoleic acid attracted far more attention from research workers. Any doubt that the EFA were required in the human was dispelled when Hansen et at. (1963) described severe MICHAEL A CRAWFORD PhD skin symptoms in infants who were fed a milk diet in which the EFAs were virtually absent (see Soderhjelm et al. 1970). Addition Nuffield Laboratories of Comparative Medicine of EFA corrected the skin symptoms. The Institute of Zoology The Zoological Society of London Until the 1960s, knowledge of the EFAs, or polyunsaturated fatty acids, was obtained through a tedious technique involving 1 Discovery of essential fatty acids and their 
TI - BACKGROUND TO ESSENTIAL FATTY ACIDS AND THEIR PROSTANOID DERIVATIVES
JF - British Medical Bulletin
DO - 10.1093/oxfordjournals.bmb.a071820
DA - 1983-01-01
UR - https://www.deepdyve.com/lp/oxford-university-press/background-to-essential-fatty-acids-and-their-prostanoid-derivatives-LZLc00ufAp
SP - 210
EP - 213
VL - 39
IS - 3
DP - DeepDyve
ER -