TY - JOUR
AU - Derudder, Emmanuel
AB - Aging results for the immune system in a departure from the optimal homeostatic state seen in young organisms. This divergence regrettably contributes to a higher frequency of compromised responses to infections and inefficient classical vaccination in aged populations. In B cells, the cornerstone of humoral immunity, the development and distribution of the various mature B cell subsets are impacted by aging in both humans and mice. In addition, aged mature B cells demonstrate limited capacity to mount efficient antibody responses. An expected culprit for the decline in effective immunity is the rise of the systemic levels of pro-inflammatory molecules during aging, establishing a chronic low-grade inflammation. Indeed, numerous alterations affecting directly or indirectly B cells in old people and mice are reminiscent of various effects of acute inflammation on this cell type in young adults. The present mini-review will highlight the possible adverse contributions of the persistent low-level inflammation observed in susceptible older organisms to the inadequate B-cell physiology.
TI - Inflammation and the Alteration of B-Cell Physiology in Aging
JF - Gerontology
DO - 10.1159/000501963
DA - 2020-03-01
UR - https://www.deepdyve.com/lp/karger/inflammation-and-the-alteration-of-b-cell-physiology-in-aging-LOYyUrvsTX
SP - 105
EP - 113
VL - 66
IS - 2
DP - DeepDyve
ER -