TY - JOUR
AU - Yudis, Melvin
AB - Abstract • Metoclopramide hydrochloride is an antiemetic and gastric motility stimulant with a wide variety of extrapyramidal side effects, including parkinsonism. We describe two patients with end-stage renal disease secondary to diabetes mellitus treated with hemodialysis who developed extrapyramidal symptoms during treatment with metoclopramide. One patient with preexisting, well-controlled Parkinson's disease developed increasing rigidity and bradykinesia that became completely refractory to treatment with L-dopa and bromocriptine while taking metoclopramide for diabetic gastroparesis. A second patient with no history of Parkinson's disease developed a resting tremor and facial dyskinesia during treatment with metoclopramide. In both cases, discontinuation of metoclopramide therapy led to prompt improvement of symptoms. (Arch Intern Med 1986;146:2070-2071) References 1. Schulze-Delrieu K: Metoclopramide. N Engl J Med 1981;305:28-33.Crossref 2. Albibi R, McCallum R: Metoclopramide: Pharmacology and clinical application. Ann Intern Med 1983;98:86-95.Crossref 3. Snape W, Battle W, Schwartz S, et al: Metoclopramide to treat gastroparesis due to diabetes mellitus. Ann Intern Med 1982;96:444-446.Crossref 4. Indo T, Ando K: Metoclopramide-induced parkinsonism. Arch Neurol 1982;39:494-496.Crossref 5. Kataria M, Traub M, Marsden C: Extrapyramidal side-effects of metoclopramide. Lancet 1978;2:1254-1255.Crossref 6. Parkes J, DeBono A, Marsden C: Bromocriptine in parkinsonism: Long-term treatment, dose response, and comparison with levodopa. J Neurol Neurosurg Psychiatry 1976;39:1101-1108.Crossref 7. Bateman D, Davies D: Pharmacokinetics of metoclopramide. Lancet 1979;1:166.Crossref 8. Bateman D: Clinical pharmacokinetics of metoclopramide. Clin Pharmacokinet 1983;8:523-529.Crossref 9. Bateman D, Gokal R, Dodd R, et al: The pharmacokinetics of single doses of metoclopramide in renal failure. Eur J Clin Pharmacol 1981;19: 437-441.Crossref 10. Caralaps A: Metoclopramide in renal failure. Lancet 1979;1:554.Crossref
TI - Metoclopramide-Induced Parkinsonism in Hemodialysis Patients: Report of Two Cases
JO - Archives of Internal Medicine
DO - 10.1001/archinte.1986.00360220252041
DA - 1986-10-01
UR - https://www.deepdyve.com/lp/american-medical-association/metoclopramide-induced-parkinsonism-in-hemodialysis-patients-report-of-LDfrMKpv3Y
SP - 2070
EP - 2071
VL - 146
IS - 10
DP - DeepDyve
ER -