TY - JOUR
AU - EDWARDS, J. H.
AB - FAMILIAL PREDISPOSITION IN MAN / . H. Edwards utilize another model, or to manage without a model and assimilate the data raw. 1. Mechanisms of Disease Not Determined by Single Factors The fundamental difficulty of devising genetic models for conditions not explicable in simple genetic terms lies in the nature of the phenotypic discontinuity, a feature elegantly explained by the half-chance of an autosomal gene's being J. H. EDWARDS M.R.C.P. passed to any child in the single-factor case. The simplest Department of Social Medicine explanation for disorders not adequately explained by single- University of Birmingham factor inheritance is to introduce the escape clause of pene- trance, so that a factor, or a pair of factors, is necessary but not sufficient. In its simplest form affliction is apparently chosen by lot. Since it is difficult to contemplate an indifference 1 Mechanisms of disease not determined by single factors 2 The single-factor and many-factor controversy of the allelic partner, of the total contribution of other genes, 3 The nature of pedigree data or of the environment, this model merges imperceptibly, as the 4 The estimation of phenotypic correlation penetrance declines, into the many-factor model to be con- 5 The problem of 
TI - FAMILIAL PREDISPOSITION IN MAN
JO - British Medical Bulletin
DO - 10.1093/oxfordjournals.bmb.a070672
DA - 1969-01-01
UR - https://www.deepdyve.com/lp/oxford-university-press/familial-predisposition-in-man-LDXsfKWMd3
SP - 58
EP - 64
VL - 25
IS - 1
DP - DeepDyve
ER -