TY - JOUR
AB - Reactions 1543, p143 - 21 Mar 2015 Toxic epidermal necrolysis and pseudomonas septicaemia: case report A 29-year-old woman developed toxic epidermal necrolysis (TEN) following therapy with ivermectin and methylprednisolone; subsequently, she died to pseudomonas septicaemia. She had a history of DRESS syndrome and Strongyloides infection. She received ivermectin and methylprednisolone [dosages and routes not stated]. Within 1 week, she developed a coalescing maculopapular rash with numerous dusky areas consistent with TEN. She was treated with immune globulin and methylprednisolone sodium succinate [solumedrol], which were ineffective. She was shifted to a burn unit and died to pseudomonas septicaemia. Author comment: "Perhaps corticosteroids and ivermectin modified the cytokine milieu from the eotaxin and IL5 environment associated with DRESS, such that re-exposure caused SJS-TEN, with characteristic keratinocyte cell death through Fas ligand." Breslin ME, et al. A fatal case of drug reaction with eosinophilia and systemic symptoms (dress)-stevens johnson (SJS)/toxic epidermal necrolysis (TEN) in the setting of strongyloides infection: Treatment considerations. Journal of Allergy and Clinical Immunology 135 (Suppl.): AB124 abstr. 399, No. 2, Feb 2015 [abstract] - USA 803116002 0114-9954/15/1543-0001/$14.95 Adis © 2015 Springer International Publishing AG. All rights reserved Reactions 21 Mar 2015 No. 1543 
TI - Ivermectin/methylprednisolone
JF - Reactions Weekly
DO - 10.1007/s40278-015-8767-1
DA - 2015-03-21
UR - https://www.deepdyve.com/lp/springer-journals/ivermectin-methylprednisolone-LD4bvvs4tX
SP - 143
EP - 143
VL - 1543
IS - 1
DP - DeepDyve
ER -