TY - JOUR
AU - Gillardin, Jean-Marie
AB - Background/Aims: Post-operative nausea and vomiting are common adverse events that require administration of anti-emetic compounds, such as the serotonin 5-HT<sub>3</sub> receptor antagonists, but these drugs can also reduce the analgesic efficacy of some analgesics (paracetamol, tramadol). Methods: The present study was designed to explore the effect of 3 serotonin 5-HT<sub>3</sub> receptor antagonists on the antinociceptive efficacy of another frequently used post-operative analgesic, nefopam, in the mouse writhing and formalin tests. Results: Pre-treatment with tropisetron, ondansetron or MDL72222 did not significantly modify nefopam antinociception in both tests. However, paracetamol antinociception was blocked by ondansetron in the formalin test. Conclusion: These results provide a rationale for the clinical use of nefopam with anti-emetics during surgery.
TI - Modulation of Paracetamol and Nefopam Antinociception by Serotonin 5-HT3 Receptor Antagonists in Mice
JF - Pharmacology
DO - 10.1159/000207448
DA - 2009-01-01
UR - https://www.deepdyve.com/lp/karger/modulation-of-paracetamol-and-nefopam-antinociception-by-serotonin-5-LBPEC1c2NA
SP - 243
EP - 246
VL - 83
IS - 4
DP - DeepDyve
ER -