TY - JOUR
AU - Press, William
AB - Abstract Background: Cultured human keratinocyte grafts have been shown to stimulate endogenous reepithelialization of both chronic nonhealing and acute partial-thickness wounds. This effect is most likely mediated by cytokines that stimulate keratinocyte growth, such as transforming growth factor alpha. The effect of cellular age on cytokine expression by cultured grafts used for this purpose is presently undefined. In this study, transforming growth factor alpha gene expression in cultured foreskin keratinocytes from donors varying in age from 2 to 82 years was analyzed semiquantitatively by two separate methods, ie, Northern hybridization and competitive polymerase chain reaction. Results: No pattern of decline in transforming growth factor alpha messenger RNA expression with increasing cellular age was observed by either analysis. 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TI - Transforming Growth Factor Alpha Gene Expression in Cultured Human Keratinocytes Is Unaffected by Cellular Aging
JF - Archives of Dermatology
DO - 10.1001/archderm.1995.01690180057011
DA - 1995-06-01
UR - https://www.deepdyve.com/lp/american-medical-association/transforming-growth-factor-alpha-gene-expression-in-cultured-human-KKAMgiC8lV
SP - 683
EP - 690
VL - 131
IS - 6
DP - DeepDyve
ER -