TY - JOUR
AU1 - Chow, Shing
AU2 - Chen, Miles
AU3 - Shi, Limin
AU4 - Chow, Albert
AU5 - Sun, Changquan
AB - Phase behaviors of 1:1 profen-nicotinamide cocrystal systems were delineated by constructing their temperature-composition phase diagrams. Cocrystallization with nicotinamide can simultaneously improve tableting behavior, hygroscopicity, and dissolution performance of ibuprofen and flurbiprofen. This could pave the way for further development of such cocrystal systems into consistent, stable, efficacious and readily manufacturable drug products.
TI - Simultaneously Improving the Mechanical Properties, Dissolution Performance, and Hygroscopicity of Ibuprofen and Flurbiprofen by Cocrystallization with Nicotinamide
JF - Pharmaceutical Research
DO - 10.1007/s11095-012-0709-5
DA - 2012-02-23
UR - https://www.deepdyve.com/lp/springer-journals/simultaneously-improving-the-mechanical-properties-dissolution-K2q6AwLjrp
SP - 1854
EP - 1865
VL - 29
IS - 7
DP - DeepDyve
ER -