TY - JOUR
AU1 - Li, Ping
AU2 - Tan, Ding
AU3 - Su, Aihua
AU4 - Xiong, Xingliang
AU5 - Gao, Shasha
AU6 - Zhang, Haiyang
AU7 - Yang, Jiaqi
AU8 - Jian, Jie
AU9 - Zheng, Jun
AU1 - Jiang, Qifeng
AB - As the incidence of chronic wounds increases, the requirements for wound dressings are rising. The specific aim of this study is to propose a novel gallic acid (GA) functionalized silk fibroin (SF) and gelatin (Gel) composite wound dressing in which GA is used as an antibacterial and wound healing substance. Via electrospinning, SF, Gel, and GA mixed solutions could be conveniently fabricated into a composite nanofiber mat (SF-Gel-GA), consisting of uniform fibers with an average diameter around 134.57 ± 84 nm. The internal mesh structure of SF-Gel-GA provides sufficient drug loading capacity, proper moisture permeability, and proper degradation rate. SF-Gel-GA presents excellent biocompatibility. NIH-3T3 fibroblast cells could adhere and spread stably on the SF-Gel-GA surface with slightly promoted proliferation. In the presence of SF-Gel-GA, the growth of both Gram-positive and Gram-negative bacteria, including Staphylococcus aureus and Pseudomonas aeruginosa, is significantly inhibited in both plate and suspension cultures. A cutaneous excisional mouse wound model proves the efficient ability of SF-Gel-GA to promote wound healing. Compared with pure SF dressing and commercial Tegaderm Hydrocolloid3M dressing, the wound closure rate with SF-Gel-GA treatment is significantly improved. The histological assessments further demonstrate SF-Gel-GA could facilitate collagen deposition, neovascularization, and epithelialization at wound sites to promote wound healing. In conclusion, a novel SF-Gel-GA composite wound dressing with efficient wound healing activities have been developed for chronic wound treatment with broad healing potential.
TI - Gallic acid functionalized silk fibroin/gelatin composite wound dressing for enhanced wound healing
JF - Biomedical Materials
DO - 10.1088/1748-605x/ad8c09
DA - 2025-01-01
UR - https://www.deepdyve.com/lp/iop-publishing/gallic-acid-functionalized-silk-fibroin-gelatin-composite-wound-Jze0o2xhYI
VL - 20
IS - 1
DP - DeepDyve
ER -