TY - JOUR
AU1 - Li, Peizhi
AU2 - Zhang, Zhao
AU3 - Gong, Jianping
AU4 - Zhang, Yan
AU5 - Zhu, Xiwen
AB - Hepatol Int (2014) 8:275–284 DOI 10.1007/s12072-014-9528-6 O R I G IN AL ARTI CL E S-Adenosylmethionine attenuates lipopolysaccharide-induced liver injury by downregulating the Toll-like receptor 4 signal in Kupffer cells • • • Peizhi Li Zhao Zhang Jianping Gong Yan Zhang Xiwen Zhu Received: 23 October 2013 / Accepted: 15 January 2014 / Published online: 8 March 2014 Asian Pacific Association for the Study of the Liver 2014 Abstract Results SAM significantly improved the survival rate of Purpose S-Adenosylmethionine (SAM) is beneficial for endotoxemic mice (p \ 0.05) and decreased TNF-a levels lipopolysaccharide (LPS)-induced liver injury, but its in serum (p \ 0.05). Simultaneously, SAM also attenuated molecular basis is not fully understood. The present study LPS-induced liver injury and expression of TLR4 and was carried out to investigate the effects of SAM on LPS MYD88 in the hepatic sinusoid. Moreover, TLR4 and signal transduction and its possible mechanism. MYD88 gene and protein expressions were downregulated Methods An animal model of LPS-induced liver injury by SAM pretreatment in LPS-stimulated KCs. Finally, was established by intraperitoneally injecting mice with SAM did not affect NF-jB-p65 translocation into the 10 mg/kg LPS pretreatment with or without SAM nucleus (p [ 0.05), but 
TI - S-Adenosylmethionine attenuates lipopolysaccharide-induced liver injury by downregulating the Toll-like receptor 4 signal in Kupffer cells
JF - Hepatology International
DO - 10.1007/s12072-014-9528-6
DA - 2014-03-08
UR - https://www.deepdyve.com/lp/springer-journals/s-adenosylmethionine-attenuates-lipopolysaccharide-induced-liver-JtHfvOq57A
SP - 275
EP - 284
VL - 8
IS - 2
DP - DeepDyve
ER -