TY - JOUR
AU - Gold, Lisa H.
AB - Psychopharmacology (1999) 147:2–4 © Springer-Verlag 1999 SHOR T REPOR T Lisa H. Gold Hierarchical strategies for phenotypic analysis can be Introduction used for multi-level analysis of behavior in mice (Rog- ers et al. 1997; Crawley 1999). These schemes consist Neuropsychiatric disorders are a major health concern. of broadly based domains and tasks in order to be able Diseases such as Alzheimer’s disease or HIV-associated to detect wide-ranging phenotypic changes. Mouse be- cognitive and motor disorder, as well as feeding disor- havioral repertoires have been well characterized and ders, depression and the effects of drug and alcohol thus they represent excellent subjects for phenotypic abuse, are far-reaching. It is becoming increasingly ap- characterization of the nervous system and behavior. parent that these and many other neuropsychiatric disor- Like other species of laboratory animals, mice can be ders result from the contribution of genetic or environ- trained in a variety of behavioral paradigms. A powerful mental factors, or a combination of the two. Unraveling method for perturbing behavior and exaggerating poten- the complexities of the molecular interactions in the tial differences between experimental groups involves brain and determining the precise roles of specific host the use of pharmacological agents (Gold 1996). 
TI - Hierarchical strategy for phenotypic analysis in mice
JF - Psychopharmacology
DO - 10.1007/s002130051127
DA - 1999-11-01
UR - https://www.deepdyve.com/lp/springer-journals/hierarchical-strategy-for-phenotypic-analysis-in-mice-JshP12VcwY
SP - 2
EP - 4
VL - 147
IS - 1
DP - DeepDyve
ER -