TY - JOUR
AU1 - Frei,, U.
AU2 - Schindler,, R.
AU3 - Wieters,, D.
AU4 - Grouven,, U.
AU5 - Brunkhorst,, R.
AU6 - Koch, K., M.
AB - Abstract Despite of advances in 1-year survival rates of renal allografts, no comparable achievements have been made in long-term graft survival. To identify risk factors for chronic progressive renal allograft dysfunction we conducted a retrospective study in 639 patients transplanted between 1983 and 1990. Graft function was assessed by the slope of individual 1/creatinine regression lines and chronic progressive graft dysfunction was defined as a slope of the 1/creatinine line of >0.1 dl/mg/year, indicating a loss of glomerular filtration rate of > 10 ml/min/year regardless of the initial serum creatinine value. A number of possible risk factors were determined and analysed by linear regression analysis. One hundred and six patients (16.6%) showed chronic progressive graft dysfunction. No correlation was found between the rate of functional deterioration and the age and gender of the donor or the recipient, the blood group, the prevalence of hepatitis B or C, the number of blood transfusions, the total ischaemia time, or the number of kidneys from female donors grafted into male recipients. Chronic progressive graft dysfunction was associated with the number of HLA-B/DR mismatches (P=0.04) and with a first acute rejection episode later than 60 days after transplantation (P<0.001). Chronic progressive graft dysfunction also occurred in the absence of an acute rejection episode. Significantly (P < 0.001) more patients with chronic progressive graft dysfunction were hypertensive not only 12 months after transplantation, but also at the time of transplantation, indicating that hypertension may not only be secondary to deteriorating graft function, but that hypertension per se leads to graft damage and initiates chronic progressive graft dysfunction. All efforts should be made to control blood pressure adequately to improve long-term survival of renal allografts. Kidney trasplantation, hypertension, chronic rejection, HLA-matching, graft survival This content is only available as a PDF. © 1995 European Dialysis and Transplant Association-European Renal Association
TI - Pre-transplant hypertension: a major risk factor for chronic progressive renal allograft dysfunction?
JF - Nephrology Dialysis Transplantation
DO - 10.1093/ndt/10.7.1206
DA - 1995-07-01
UR - https://www.deepdyve.com/lp/oxford-university-press/pre-transplant-hypertension-a-major-risk-factor-for-chronic-JocjVhT6gu
SP - 1206
EP - 1211
VL - 10
IS - 7
DP - DeepDyve
ER -